It used to be the case (considerably less so today) that a significant fraction of women in central Africa, up to tens of percent in some areas, were infertile or subfertile, due to various STDs. This seems to have been true for quite a while, up until the 1990s and back some indefinite amount of time, probably at least one or two centuries. It might be older than that, but at this point nobody knows. There was enough infertility that colonial administrators worried about keeping up the population, in the days before readily available antibiotics: for example, the population of Gabon seems to have decreased between 1930 and 1950.
Most of this infertility was caused through tubal scarring caused by gonorrhea and chlamydial infections.
If this pattern was around long enough, there could have been significant selection for resistance to the relevant pathogens, possibly generating high frequencies of alleles with odd or unpleasant side effects, as with malaria and sickle-cell/thalassemia etc. This would depend on the age of the behavior patterns that made this possible, on the antiquity of the pathogens causing those STDs, etc.