There have been several articles in the literature claiming that the gene frequency of the 35delG allele of connexin-26, the most common allele causing deafness in Europeans, has doubled in the past 200 years, as a result of relaxed selection and assortative mating over that period.
That’s fucking ridiculous. I see people referencing this in journal articles and books. It’s mentioned in OMIM. But it’s pure nonsense.