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Meta
Category Archives: Genetics
Ketosis as a way of life
There’s a new article out in ASHG that discusses a regional selective sweep in CPT1A, carnitine palmitoyltransferase 1A, which plays an essential role in fatty acid metabolism. A mutation has become extremely common, with a gene frequency > 50%, in … Continue reading
Ust’-Ishim & the Old Race
There’s a new report out in Nature, on the DNA results from a 45,000 AMH skeleton found in Western Siberia. It’s the oldest radiocarbon-dated modern human outside Africa and the Middle East. The Neanderthal admixture is there, about the same … Continue reading
Posted in Archaic humans, European Prehistory, Genetics, Neanderthals
Tagged Basal Eurasian
30 Comments
We Three Kings
A recent article says that 40% of Chinese Y-chromosomes originated from 3 men in the late neolithic. This pattern, fantastic success for a particular paternal lineage, has been seen before, with the Golden Family (descendants of Genghis Khan) and the … Continue reading
Posted in Genetics
54 Comments
Powerful Stuff
I was thinking again about that Denisovan allele of EPAS1 that plays a big role in Tibetan altitude adaptation. Considering modern humans, it has only been found in Tibetans (high frequency) and in the Chinese (couple of percent). The preferred … Continue reading
Posted in Altitude adaptations, Denisovans, Genetics
18 Comments
Rasmus Nielsen
The paper on the Denisovan origin of one of the key altitude-adaptation genes (EPAS1) in Tibetans is now out (lead author Emilia Huerta-Sanchez, senior author Rasmus Nielsen). It’s on a Denisovan haplotype. Likely Denisovans occupied a lot of East … Continue reading
Posted in Altitude adaptations, Denisovans, Genetics
22 Comments
Ashkenazi Ancestry
I’m looking at abstracts on Ashkenazi genetics from ASHG 2013 and SMBE 2014 – by the same group, with Shai Carmi as the lead author. They did 128 whole genomes, 50x deep. They concluded Ashkenazi Jews were about 50% Middle … Continue reading
Posted in Ashkenazi Jews, Genetics
94 Comments
Diversity Galor
Quamrul Ashraf and Oded Galor argue that “the level of genetic diversity within a society is found to have a hump-shaped effect on development outcomes in both the pre-colonial and the modern era, reflecting the trade-off between the beneficial and … Continue reading
Posted in Economics, Genetics
66 Comments
Talking to Economists
I gave a talk, back in April, at the University of Chicago. We were trying to introduce some economists to genetics, which is relevant to some of the questions they work on. Some already knew quite a bit – we … Continue reading
Posted in Economics, Genetics
90 Comments
Call Him George
One thing leads to another. I hear that Rasmus Nielsen (speaking at SMBE 2014) has evidence that Tibetans picked up some of their altitude adaptation (EPAS1) from Denisovans. Who could have imagined that?
Posted in Altitude adaptations, Denisovans, Genetics
14 Comments
Neanderthal Man: In Search of Lost Genomes
Svante Pääbo has a book out, Neanderthal Man, in which he recounts his adventures sequencing ancient DNA. He has had three big successes: the first successful sequencing of Neanderthal mtDNA in 1997, the first sequencing of the Neanderthal nuclear genome, … Continue reading
Posted in Archaic humans, Book Reviews, Denisovans, Genetics, Neanderthals
118 Comments