There are a couple of new papers out in Cell about demonstrated immunological differences between Africans and Europeans. We already knew that the course of various infectious diseases can be quite different in people from those two different races, while autoimmune risks are also different (lupus for example is considerably more common in blacks). Researchers found that inflammatory responses were considerably stronger in Africans than Europeans. African macrophages zapped bacteria three times faster than European macrophages.
I wonder if this increased inflammatory tendency is behind the increased risk for sarcoidosis in blacks (12-fold higher death rate). If so, maybe you could help the clinical course by damping down inflammation.
The African pattern almost certainly worked better in Africa (chock-full o’ of pathogens, including many adapted to man or close relatives), while the European pattern worked better outside of Africa – on the whole cooler and less of a microbial playpen.
Henry and I, along with others, put out a paper on this subject a few years ago.
Some of the milder-inflammation alleles in Europeans originated in Neanderthals. Logical, since they too had adapted to the lower pathogen load in ice-age Europe and Central Asia. This probably meant that Neanderthals couldn’t have returned to Africa.
This is all impossible if race does not exist, or if Lewontin had had anything to valid to say on the subject. Of course race does exist, while Lewontin is a fountain of nonsense.